Expert Pearls
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Alzheimers Disease - curcumin - 47274 Curcumin BCM-95 1 - 4 gm/d with food. [Journal of Clinical Psychopharmacology, 2008;28:110-13. 47274 (7/2009)] Summary Interview PubMed |
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Alzheimer’s Disease - diet - 34806 Diet low in fat and total energy, increased in fruits, vegetables and whole grains reduces the risk of Alzheimer’s disease. J Alzheimer’s Dis 1999 1 197-201 34806 1999 Summary Interview PubMed |
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Alzheimer’s Disease - diet - 34806 Diet after age 60 predominant risk factor. J Alzheimer’s Dis 1999 1 197-201 34806 1999 Summary Interview PubMed |
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Alzheimer’s Disease - diet - 42067 Diet high in total carbohydrate (refined or unrefined) with APOE4 allele (inhibit lipid metabolism similar to a high carbohydrate diet) increases risk. Medical Hypothesis 2004 62 689-700 42067 11/2004 Summary Interview PubMed |
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Alzheimer’s Disease - fat - 34806 Fat - high in total fat, saturated fat and cholesterol increase risk. [J Alzheimer’s Dis, 1999;1:197-201. 34806 1999)] J Alzheimer’s Dis 1999 1 197-201 34806 1999 Summary Interview PubMed |
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Alzheimer’s Disease - faty acids - 42067 Fatty acids - increase the omega 3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Medical Hypothesis 2004 62 689-700 42067 11/2004 Summary Interview PubMed |
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Alzheimer’s Disease - fish - 34806 Fish consumption reduced risk. J Alzheimer’s Dis 1999 1 197-201 34806 1999 Summary Interview PubMed |
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Alzheimer’s Disease - folic acid (serum) - 37878 Folic acid (serum) less than 13 nmol/L and vitamin B12 (serum) less than 251 pmol/L increases risk. [Neurology 2001;56:1188-1194 37878 2001] Summary Interview PubMed |
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Alzheimer’s Disease - genetics - apoe4 allele - 34806 Genetics - APOE4 allele is associated with an increased risk; only 10 % of Alzheimer’s disease is related to genetics. [J Alzheimer’s Dis, 1999;1:197-201 34806 1999] Summary Interview PubMed |
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Alzheimer’s Disease - ginkgo biloba - 24968 Ginkgo biloba special extract Egb 761® 240 mg/d. Pharmacopsychiat 1996 29 47-56 24968 1996 Summary Interview PubMed |
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Alzheimer’s Disease - ginkgo biloba - 46792 Ginkgo biloba special extract Egb 761® 240 mg/d. Alzheimer's and Dementia July 2008 4 4 Supplement, T165-T166 46792 11/2008 Summary |
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Alzheimer’s Disease - homocysteine - 39403 Homocysteine (a functional test for vitamin B12) is inversely related to Alzheimer’s disease/cognitive decline. Folic acid 1 mg/d, vitamin B12 500 mcg/d, vitamin B6 40 mg/d may lower homocysteine levels. Neurology 2002 58 1395-1399 39403 2002 Summary Interview PubMed |
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Alzheimer’s Disease - melatonin - 34948 Melatonin reduces formation of beta-amyloid. J Applied Nutr 1999 51 1 3-15 34948 2000 Summary Interview |
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Alzheimer’s Disease - melatonin - 45955 Melatonin 3-6 mg (fast-release) at bedtime may improve cognitive function. J Pineal Res 2007 43 4 404-409 45955 3/2008 Summary Interview PubMed |
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Alzheimer’s Disease - mitochondrial energy - 34948 Mitochondrial energy production deficit (acetyl-l-carnitine, CoQ10, phosphatidylserine, magnesium enhance mitochondrial ATP production). J Applied Nutr 1999 51 1 3-15 34948 2000 Summary Interview |
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Alzheimer’s Disease - nadh - 24840 NADH 2 - 5 mg tablets/d. Annals of Clinical and Laboratory Science 1996 26 1 1-9 24840 1996 Summary Interview PubMed |
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Alzheimer’s Disease - nadh - 34948 NADH 2 - 5 mg tablets/d. J Applied Nutr 1999 51 1 3-15 34948 2000 Summary Interview |
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Alzheimer’s Disease - nutraceutical combination Nutraceutical Combination - Folic acid 400 mcg/d, vitamin E 30 IU/d, vitamin B12 6 mcg/d, S-adenosyl methionine 400mg/d, N-acetylcysteine 600mg/d and acetyl-L-carnitine 500 mg/d in 2 pills per day taken at any time improved cognition and mood. [J Alzheimer's Dis Other Demen, Feb-Mar 2009;24(1):27-33. Epub 2008 Dec 3 ] Summary Interview PubMed |
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Alzheimer’s Disease - nutraceutical combination - 46908 Nutraceutical Combination - Folic acid 400 mcg/d, vitamin E 30 IU/d, vitamin B12 6 mcg/d, S-adenosyl methionine 400mg/d, N-acetylcysteine 600mg/d and acetyl-L-carnitine 500 mg/d in 2 pills per day taken at any time improved cognition and mood. [ Am J Alzheimer's Dis Other Demen, Dec 2008 – Jan 2009;23(6):571-85. Epub 2008 Dec 1]. 46908 (2/2009)] Summary Interview PubMed |
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Alzheimer’s Disease - pesticide exposure - 34948 Pesticide exposure. J Applied Nutr 1999 51 1 3-15 34948 2000 Summary Interview |
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Alzheimer’s Disease - vitamin b1 - 23739 Vitamin B1 (thiamine) plasma levels significantly lower; antecdotal improvement vitamin B1 3-5 gm/d. Archives of Neurology November 1995 52 1081-1085 23739 1996 Summary Interview PubMed |
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Alzheimer’s Disease - vitamin b12 - 28725 Vitamin B12 normal ranges should be 600 to 2000 pg/ml. Below 550 to 600 pg/ml deficiencies start to appear in the CSF. Humans are born with serum levels of about 2000 pg/ml, which decline gradually throughout life. Medical Hypotheses 1991 34 131-140 28725 1998 Summary Interview PubMed |
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Alzheimer’s Disease - vitamin b12 - 37878 Vitamin B12 (serum) less than 251 pmol/L and folic acid (serum) less than 13 nmol/L increases risk. Neurology 2001 56 1188-1194 37878 2001 Summary Interview PubMed |
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Alzheimer’s Disease - vitamin b12 - 39403 Vitamin B12 functional deficiency occurs from Alzheimer’s disease-related oxidative stress. Neurology 2002 58 1395-1399 39403 2002 Summary Interview PubMed |
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Alzheimer’s Disease - vitamin B12 - 46641 Vitamin B12 - low levels associated with reduced brain volume. B12 levels >300 pmol/L (406.5 pg/ml) may be protective. Neurology 2008 71 11 826-32 46641 10/2008 Summary Interview PubMed |
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Alzheimer’s Disease - vitamin b3 - 42169 Vitamin B3 (niacin) from diet at 22.4 mg/d (highest quintile) compared with the 12.6 mg/d (lowest quintile) resulted in a 70% reduction in risk. J Neurol Neurosurg Psychiatry 2004 75 1093-1099 42169 12/2004 Summary Interview PubMed |
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Alzheimer’s Disease - vitamin e - 39518 Vitamin E high in diet reduced risk significantly. JAMA June 26 2002 287 24 3230-3237 39518 2002 Summary Interview PubMed |
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Alzheimer’s Disease - zinc - 24249 Zinc bound thymulin in plasma is very low. Biological Trace Element Research 1996 51 55-61 24249 1996 Summary Interview PubMed |
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